Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
Best wishes for the holidays and happiness throughout the New Year.
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
The Peoria, Ill.-based maker of heavy equipment authorized $10 billion in stock repurchases in January and expected to buy back $1.7 billion of its shares in the first quarter this year to complete its previous $7.5 billion repurchase initiative. The ongoing buybacks are "a result of our record cash flow," said CEO Doug Oberhelman.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Best Companies rank: 61
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
Auto sales: Car sales reach 17 million but manufacturers scramble to adjust capacity as trucks and SUVs soar in popularity. Pressure to hold down corporate fuel averages drives margins on small cars far below break-even.
The history of James Bond theme songs isn't quite as long as some might suspect, however. The first two films in the series – Dr. No and From Russia With Love – didn't have opening songs, they had orchestral arrangements. Dr. No even segued into a weird rendition of "Three Blind Mice." Later on, On Her Majesty's Secret Service gave the opening number amiss and snuck its theme song into the middle and end of the movie.
Trends and targets in antiviral phototherapy
根据荷兰经济政策研究局(Netherlands Bureau for Economic Policy Analysis)发布的《世界贸易监测》(World Trade Monitor)报告，以美元计算，去年跨越国际边境的商品总价值下降了13.8%，是自2009年以来的首次萎缩。这一暴跌很大程度上源于中国和其他新兴经济体的放缓。
●"Cinnamon Roll Can Explodes Inside Man’s Butt During Shoplifting Incident"
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
If it isn't appropriate to interrupt, make a quick note of your question so you don't forget, and ask later.
Novel biosensing methodologies for ultrasensitive detection of viruses
Among the year’s biggest surprises was the plunge in gasoline pries. Economists differed on the economic impact—money in the pockets of consumers offset by declines in exploration and drilling activity—but everyone agreed that it was bearish for small cars and hybrids. The combination of cheap gas and a steep sticker price made the Cadillac ELR the runaway winner of the most disliked car of the year award. Only 155 of the Volt-based $80,000 cars found buyers in November.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
ACE2 as a potential therapeutic target for pandemic COVID-19
Diagnostic technologies for COVID-19: a review
Since you will be spending so much time in your office space, you should be comfortable enough to enjoy what you do. A comfy chair will keep you pleased throughout the day. We recommend the Allak Swivel Chair, $59.99, at Ikea.com. If you need music to keep your mind stirring, we recommend the Sound System iPod Speaker, $220, at UrbanOutfiters.com.
WHAT: A riverfront contemporary with three bedrooms and three and a half bathrooms
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
bend的过去式和过去分词 adj. 下定决心的，弯曲的
6. 现在，就像瘾君子戒不了毒一样，格罗斯在其博客“Tipping Point”中写道，QE将维持到2015年。“暂时没有名字的泡沫”早前似乎应该改名叫“贝南克泡沫”。但现在事关格罗斯及其太平洋投资管理公司(Pimco)的二万亿美元，或许我们应该称之为“格罗斯泡沫”。
Banks just cannot afford to keep up. At Goldman Sachs, for example, net revenues have dropped about a third since 2009, beaten down by structural shifts in trading and new rules crimping risk-taking. The bank tries to keep its pay ratio stable, so that means smaller total packages for the typical employee.
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
"Although it may seem counterintuitive, the best way to maximize profits over the long-term is not to make them the primary goal of the business," Mackey said in an interview earlier this year.
Set in 1950's London, Reynolds Woodcock is a renowned dressmaker whose fastidious life is disrupted by a young, strong-willed woman, Alma, who becomes his muse and lover.
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
Critics have been eager to point out that he is not so closely involved in new product development as his predecessor, and fails to elicit the same excitement when he takes to the stage to introduce them. But Mr Cook is aware of his shortcomings and has drawn on the worlds of fitness and fashion to assemble a new team of talents, including Angela Ahrendts, formerly of Burberry, and industrial designer Marc Newson.
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
7. Viceroy's House
Antiviral drug discovery: broad-spectrum drugs from nature
Consumer prices rose 2.3 per cent year-on-year, more than expectations of 1.8 per cent. That is the biggest rise since July 2014. They had risen 1.8 per cent in January.
Peace and love for you at New Year from all your students.祝老师新年充满平安和爱。
Influenza neuraminidase: A druggable target for natural products
Anxiety about addiction to screen time gave rise to a dubious new line of businesses: boot camps, often run by ex-military personnel, promising to help wayward youth kick the habit. But investigative reports p ublished in recent days by Beijing News and the Mirror reveal abusive conditions, leading to the death of at least one student, at the Zhengzhou Boqiang New Idea Life Training School, which billed itself a s an Internet-addiction recovery camp in eastern Henan province.
Some scientists believe people with excellent recall and the ability to remember everything use a special mental filing system to keeping things organized in their memories. Mental tricks are also used by magicians to wow audiences with seemingly impossible feats of memory. But do you need to know special tricks or have an eidetic memory to remember everything? If you're worried you've forgotten more in life than you ever knew, don't worry. Science has you covered! Check out these 10 scientific secrets to a perfect memory.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
It will be interesting to see which direction they go at the trade deadline. They have a handful of solid players along with Brook Lopez.
The role of biosensors in the detection of emerging infectious diseases
Writing for a Variety Special: Patton Oswalt, “Patton Oswalt: Talking for Clapping”
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Hitachi Data Systems
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
Two Chinese universities, University of Hong Kong and University of Macao, squeezed into the top 10 of the world's most international universities in 2016, according to a new list published by Times Higher Education on Thursday.
The consequences are more parochial than those of Chinese data distortion. British law requires the ONS to produce the RPI and, given that it refuses to improve the measure, its fiddling affects hundreds of billions of pounds of contracts which continue to be linked to the RPI.
《国土安全》(Homeland)：第三季末布洛迪（Brody，戴米恩·路易斯[Damian Lewis]饰）最终被杀后，映时频道(Showtime)的这部间谍惊悚剧似乎走到了尽头。目前看来，第四季没了他却变得充满活力，令人喜爱。卡莉（Carrie，克莱尔·丹尼斯[Claire Danes]饰）这次的对手是美貌、狡猾的巴基斯坦情报官塔斯尼姆（Tasneem，尼姆拉特·考尔[Nimrat Kaur]饰）。
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
For the first time, it’s a blend of two colors: Rose Quartz (a kind of mineral pink) and Serenity (a light blue). On the company’s website, the colors flow seamlessly into each other so that it’s impossible to tell where one begins and the other ends.
Roth, 60, is a professor at Harvard University in Boston. Shapley, 89, is a professor emeritus at University of California Los Angeles.
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
The show started with a circus theme, complete with acrobats, a sword-swallower and a man on stilts. Justin Bieber, Rihanna and Bruno Mars performed.
Inhibition of SARS coronavirus helicase by bismuth complexes
We will promote a steady increase in consumer spending.
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
皮耶里在大型消费类产品公司工作过多年，如Stride Rite和科迪斯（Keds）等。所以，这种夫妻店在推出新产品时所遇到的困难令皮耶里感到失望。她解释道：“越创新的产品，因为与主流和‘已知’相悖，因而越难销售。”因此，她在五年前成立了The Grommet，这个信息分享平台会将消费者与发明者的故事和产品联系起来。皮耶里的公司帮助发布的产品包括自制碳酸饮料机Sodastream和智能腕带Fitbit。她一直把惠普公司（HP）CEO梅格惠特曼作为自己的导师，并在哈佛商学院（Harvard Business School）担任入驻企业家。
The Chinese-made 3D fantasy/adventure film "Monster Hunt" broke a string of box-office records on its release in the country in July 2015, becoming the highest grossing film of the year in the Chinese mainland.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
As for the worst job of 2013? Newspaper reporter bumped last year's loser, lumberjack, for the ignominious distinction.
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
Given a choice, Chinese university graduates prefer to find employment rather than start a company.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
Fast & Furious 6 helped place two other actors high on our list: Vin Diesel and the late Paul Walker. Diesel lands in fourth place with $887 million. Fast & Furious 6 earned $789 million at the box office worldwide. The third movie in his Riddick franchise hit theaters just a few months after. It only pulled in $98 million, but that was enough to put Diesel ahead of his co-star Walker on our list.
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
8. Your appendix might not be a useless evolutionary byproduct after all. Unlike your wisdom teeth, your appendix might actually be serving an important biological function - and one that our species isn't ready to give up just yet.
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
6) My Pleasure: This subtle reminder reinforces a key point. You’re here to help others. You have all the time they need. And you’re happy to do it.
n. 宣言，声明 vi. 发表宣言
Phil Baty, editor of THE rankings, said: "China has introduced powerful policy drives, backed with serious funding, to produce world-class universities. In 2015, the country announced its excellence initiative, which aims to establish six of its universities in the leading group of global institutions by 2020."
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
Exports had risen in renminbi terms last month as well, up 5.9 per cent. But when valued in dollars they grew only 0.1 per cent year on year to $196.8bn. Still, that was well above expectations of a 5 per cent fall after contraction had softened somewhat in October to 7.3 per cent.
Fiat will seek to renegotiate the terms of its investment in Chrysler.
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
“These students have absolutely no free speech rights that were violated in this context."
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
These countries performed the best overall in the 2017 Best Countries rankings. The rankings aim to gauge global perceptions of the world’s biggest economies.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
How has your trip to the US sofar this summer?
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
Metals cases made up a record 46 per cent of the 233 anti-dumping actions brought worldwide in 2015, with the steel industry accounting for almost all of the metals complaints.
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
Meanwhile, there are other factors holding back the Asian ETF market that some sceptics fear will hold back development of the retail side.
In 2013, the total number of applicants who qualified for the national service exam reached a record 1.52 million. In 2014, the total number decreased for the first time in four years to 1.41 million, the People's Daily website said.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
“This is not an excuse — this is the reality of the environment we operate in, ” Dervin said. Since 2012, JetBlue has been implementing a series of technology efforts to help it recover more quickly from bad weather. She said other tools are coming online that will help the airline keep to its schedules.
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
Remember, no one is ever perfectly prepared for every situation. You’ve probably discovered this by now. Your education gave you a foundation for the job, but growth happens in the trenches. Maybe you motivated your team not just to meet the new deadline, but to deliver extraordinary work. Perhaps you realized you had more poise than you ever expected in a client situation. Or, you suddenly discovered that you can capitalize on the relationships you’ve built and become a “rainmaker” for your organization. Before you can learn any of these things, you have to learn to say “Yes.” It’s okay to acknowledge the butterflies in your stomach; however, it’s not okay to let them stifle your growth.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
China's mass entrepreneurship and innovation initiative has a strong vitality.
A facile assay for rapid detection of COVID-19 antibodies
Social networking platforms, including Weibo and mobile app WeChat, proved to be the best tools for cyberstars to magnify the power of communication, making it possible to create an industry that combines advertisements, e-commerce and fans.
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
'My first duty, my first responsibility was to be true to the original feel of the book, to be true to Ian Fleming: his creation, his world and his ideas.
The local court gave Zhou a lenient sentence due to the teenager's age and frank confession of the crime, according to the report.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
I don't know about you, but if I had a separate calendar for work, school and life, I'd be a complete mess. When everything in your life is on one calendar, in one planner, you can't double-book anything. You know, like an important test and a dinner with your boss.
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
The below are 5 companies that stand out from the rest and are startups to watch in 2014.
Extreme heat blanketed Alaska and much of the western United States last year. Records were set across large areas of every inhabited continent. And the ocean surface was unusually warm virtually everywhere except near Antarctica, the scientists said, providing the energy that fueled damaging Pacific storms.
Since then, China has been issuing stamps on the theme of the lunar calendar every year to mark the 12 Chinese astrological signs.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
'She does wear wigs and crowns and fancy dresses but I don't give her spray tans or cake her in makeup - I'll wait until she's about five for that.'
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
People have been predicting consolidation in this very fragmented sector for years and there have indeed been big mergers recently. But there is little doubt that price pressures on City law firms are intensifying.
Anti-HIV drug repurposing against SARS-CoV-2
Length-scale dependence of protein hydration-shell density
6. "How I Met Your Mother" (3.0 million)
Despite car and truck sales that motored past 16 million for the first time since 2007, recalls dominated the news for most of the year. General Motors GM 1.42% held center stage, dealing with cascading revelations about faulty ignition switches and recalling millions of vehicles. While GM opted for something approaching full disclosure of its missteps , publishing an report into company-wide fumbles, Japanese airbag maker Tanaka chose to stonewall. It left any remedies up to its beleaguered customers, notably Honda and Toyota. They are the ones who deal with the fallout of exploding safety devices that fatally fired shrapnel throughout the passenger compartment.
Tsinghua University and Peking University are ranked in 14th and 17th place respectively -- the same positions they held in last year's rankings.
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
《嘻哈帝国》(Empire)，Fox，周三播出。这部最新的嘻哈乐肥皂剧的导演是电影人李·丹尼尔斯(Lee Daniels)，他曾执导《珍爱》(Precious)和《白宫管家》(Lee Daniels’ The Butler)）。片中泰伦斯·霍华德(Terrence Howard)饰演一个身患致命疾病的说唱乐大明星。
To Japanese creators Kazutaka Kurihara and Koji Tsukada for developing the SpeechJammer, a device that uses delayed auditory feedback to shut up participants in a discussion. This kind of system has been used in speech therapy to reduce stuttering among those with that particular speech disturbance.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Specifically, the SAPPRFT said the total box office of China in 2016 reached 45.7 billion yuan (around 6.6 billion USD), an increase of 3.7 percent over 2015.
1. China’s Economy.China is the second largest consumer of oil in the world and surpassed the United States as the largest importer of liquid fuels in late 2013. More importantly for oil prices is how much China’s consumption will increase in the coming years. According to the EIA, China is expected burn through 3 million more barrels per day in 2020 compared to 2012, accounting for about one-quarter of global demand growth over that timeframe. Although there is much uncertainty, China just wrapped up a disappointing fourth quarter, capping off its slowest annual growth in over a quarter century. It is not at all obvious that China will be able to halt its sliding growth rate, but the trajectory of China’s economy will significantly impact oil prices in 2015.
About this collection